[HTML][HTML] MMSET deregulation affects cell cycle progression and adhesion regulons in t (4; 14) myeloma plasma cells
haematologica, 2009•ncbi.nlm.nih.gov
Background The recurrent immunoglobulin translocation, t (4; 14)(p16; q32) occurs in 15%
of multiple myeloma patients and is associated with poor prognosis, through an unknown
mechanism. The t (4; 14) up-regulates fibroblast growth factor receptor 3 (FGFR3) and
multiple myeloma SET domain (MMSET) genes. The involvement of MMSET in the
pathogenesis of t (4; 14) multiple myeloma and the mechanism or genes deregulated by
MMSET upregulation are still unclear.
of multiple myeloma patients and is associated with poor prognosis, through an unknown
mechanism. The t (4; 14) up-regulates fibroblast growth factor receptor 3 (FGFR3) and
multiple myeloma SET domain (MMSET) genes. The involvement of MMSET in the
pathogenesis of t (4; 14) multiple myeloma and the mechanism or genes deregulated by
MMSET upregulation are still unclear.
Abstract
Background
The recurrent immunoglobulin translocation, t (4; 14)(p16; q32) occurs in 15% of multiple myeloma patients and is associated with poor prognosis, through an unknown mechanism. The t (4; 14) up-regulates fibroblast growth factor receptor 3 (FGFR3) and multiple myeloma SET domain (MMSET) genes. The involvement of MMSET in the pathogenesis of t (4; 14) multiple myeloma and the mechanism or genes deregulated by MMSET upregulation are still unclear.
ncbi.nlm.nih.gov
