The Slit family of secreted proteins and their transmembrane receptor, Robo, were originally
identified in the nervous system where they function as axon guidance cues and branching
factors during development. Since their discovery, a great number of additional roles have
been attributed to Slit/Robo signaling, including regulating the critical processes of cell
proliferation and cell motility in a variety of cell and tissue types. These processes are often
deregulated during cancer progression, allowing tumor cells to bypass safeguarding …