Midline crossing and Slit responsiveness of commissural axons require USP33
J Yuasa-Kawada, M Kinoshita-Kawada, G Wu… - Nature …, 2009 - nature.com
J Yuasa-Kawada, M Kinoshita-Kawada, G Wu, Y Rao, JY Wu
Nature neuroscience, 2009•nature.comCommissural axons cross the ventral midline of the neural tube in a Slit-dependent manner.
The underlying molecular mechanisms remain unclear. We found that the deubiquitinating
enzyme USP33 interacts with the Robo1 receptor. USP33 was essential for midline crossing
by commissural axons and for their response to Slit. Our results reveal a previously unknown
role for USP33 in vertebrate commissural axon guidance and in Slit signaling.
The underlying molecular mechanisms remain unclear. We found that the deubiquitinating
enzyme USP33 interacts with the Robo1 receptor. USP33 was essential for midline crossing
by commissural axons and for their response to Slit. Our results reveal a previously unknown
role for USP33 in vertebrate commissural axon guidance and in Slit signaling.
Abstract
Commissural axons cross the ventral midline of the neural tube in a Slit-dependent manner. The underlying molecular mechanisms remain unclear. We found that the deubiquitinating enzyme USP33 interacts with the Robo1 receptor. USP33 was essential for midline crossing by commissural axons and for their response to Slit. Our results reveal a previously unknown role for USP33 in vertebrate commissural axon guidance and in Slit signaling.
nature.com
