[HTML][HTML] Activated platelets interfere with recruitment of mesenchymal stem cells to apoptotic cardiac cells via high mobility group box 1/Toll-like receptor 4-mediated …
S Vogel, M Chatterjee, K Metzger, O Borst… - Journal of Biological …, 2014 - ASBMB
Recruitment of mesenchymal stem cells (MSC) following cardiac injury, such as myocardial
infarction, plays a critical role in tissue repair and may contribute to myocardial recovery.
However, the mechanisms that regulate migration of MSC to the site of tissue damage
remain elusive. Here, we demonstrate in vitro that activated platelets substantially inhibit
recruitment of MSC toward apoptotic cardiac myocytes and fibroblasts. The alarmin high
mobility group box 1 (HMGB1) was released by platelets upon activation and mediated …
infarction, plays a critical role in tissue repair and may contribute to myocardial recovery.
However, the mechanisms that regulate migration of MSC to the site of tissue damage
remain elusive. Here, we demonstrate in vitro that activated platelets substantially inhibit
recruitment of MSC toward apoptotic cardiac myocytes and fibroblasts. The alarmin high
mobility group box 1 (HMGB1) was released by platelets upon activation and mediated …
