[HTML][HTML] Kinetics and specificity of feline leukemia virus subgroup C receptor (FLVCR) export function and its dependence on hemopexin
Z Yang, JD Philips, RT Doty, P Giraudi… - Journal of Biological …, 2010 - ASBMB
The feline leukemia virus subgroup C receptor (FLVCR) is a heme export protein that is
required for proerythroblast survival and facilitates macrophage heme iron recycling.
However, its mechanism of heme export and substrate specificity are uncharacterized. Using
[55 Fe] heme and the fluorescent heme analog zinc mesoporphyrin, we investigated
whether export by FLVCR depends on the availability and avidity of extracellular heme-
binding proteins. Export was 100-fold more efficient when the medium contained hemopexin …
required for proerythroblast survival and facilitates macrophage heme iron recycling.
However, its mechanism of heme export and substrate specificity are uncharacterized. Using
[55 Fe] heme and the fluorescent heme analog zinc mesoporphyrin, we investigated
whether export by FLVCR depends on the availability and avidity of extracellular heme-
binding proteins. Export was 100-fold more efficient when the medium contained hemopexin …
