Typhoid fever: pathogenesis and immunologic control
RB Hornick, SE Greisman, TE Woodward… - New England journal …, 1970 - Mass Medical Soc
RB Hornick, SE Greisman, TE Woodward, HL DuPont, AT Hawkins, MJ Snyder
New England journal of medicine, 1970•Mass Medical SocContribution of Bacterial Endotoxin Endotoxin is obviously an important component of any
gram-negative rod such as the typhoid bacillus. Vi antigen appears important in enhancing
human virulence of typhoid strains. It is not as simple to define the importance of endotoxin
since this substance has many biologic and pharmacologic activities. Attempts were made in
the course of these investigations to gather information on the role of purified endotoxin in
the pathogenesis of typhoid fever by quantitating the response to endotoxin's pyrogenic …
gram-negative rod such as the typhoid bacillus. Vi antigen appears important in enhancing
human virulence of typhoid strains. It is not as simple to define the importance of endotoxin
since this substance has many biologic and pharmacologic activities. Attempts were made in
the course of these investigations to gather information on the role of purified endotoxin in
the pathogenesis of typhoid fever by quantitating the response to endotoxin's pyrogenic …
Contribution of Bacterial Endotoxin
Endotoxin is obviously an important component of any gram-negative rod such as the typhoid bacillus. Vi antigen appears important in enhancing human virulence of typhoid strains. It is not as simple to define the importance of endotoxin since this substance has many biologic and pharmacologic activities. Attempts were made in the course of these investigations to gather information on the role of purified endotoxin in the pathogenesis of typhoid fever by quantitating the response to endotoxin's pyrogenic activity in volunteers with and without typhoid fever.
When 0.25 µg of a purified endotoxin from S. typhosa was . . .
The New England Journal Of Medicine