O-GlcNAc glycosylation (O-GlcNAcylation) corresponds to the addition of N-
acetylglucosamine on serine and threonine residues of cytosolic and nuclear proteins. O-
GlcNAcylation is a dynamic post-translational modification, analogous to phosphorylation,
that regulates the stability, the activity or the subcellular localisation of target proteins. This
reversible modification depends on the availability of glucose and therefore constitutes a
powerful mechanism by which cellular activities are regulated according to the nutritional …