[HTML][HTML] Antagonism of rat β-cell voltage-dependent K+ currents by exendin 4 requires dual activation of the cAMP/protein kinase A and phosphatidylinositol 3-kinase …
PE MacDonald, X Wang, F Xia, W El-Kholy… - Journal of Biological …, 2003 - ASBMB
Antagonism of voltage-dependent K+(Kv) currents in pancreatic β-cells may contribute to the
ability of glucagon-like peptide-1 (GLP-1) to stimulate insulin secretion. The mechanism and
signaling pathway regulating these currents in rat β-cells were investigated using the GLP-1
receptor agonist exendin 4. Inhibition of Kv currents resulted from a 20-mV leftward shift in
the voltage dependence of steady-state inactivation. Blocking cAMP or protein kinase A
(PKA) signaling (Rp-cAMP and H-89, respectively) prevented the inhibition of currents by …
ability of glucagon-like peptide-1 (GLP-1) to stimulate insulin secretion. The mechanism and
signaling pathway regulating these currents in rat β-cells were investigated using the GLP-1
receptor agonist exendin 4. Inhibition of Kv currents resulted from a 20-mV leftward shift in
the voltage dependence of steady-state inactivation. Blocking cAMP or protein kinase A
(PKA) signaling (Rp-cAMP and H-89, respectively) prevented the inhibition of currents by …
