Roles of cADPR and NAADP in pancreatic cells
Y Zhao, R Graeff, HC Lee - Acta Biochim Biophys Sin, 2012 - academic.oup.com
Y Zhao, R Graeff, HC Lee
Acta Biochim Biophys Sin, 2012•academic.oup.comCyclic ADP-ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate (NAADP)
are Ca2+-mobilizing nucleotides that were discovered in the late 1980s. Two decades of
investigations have built up a considerable understanding about these two molecules that
are related because both are derived from pyridine nucleotides and known to be generated
by CD38/ADP-ribosyl cyclases. cADPR has been shown to target the ryanodine receptors in
the endoplasmic reticulum whereas NAADP stimulates the two-pore channels in the endo …
are Ca2+-mobilizing nucleotides that were discovered in the late 1980s. Two decades of
investigations have built up a considerable understanding about these two molecules that
are related because both are derived from pyridine nucleotides and known to be generated
by CD38/ADP-ribosyl cyclases. cADPR has been shown to target the ryanodine receptors in
the endoplasmic reticulum whereas NAADP stimulates the two-pore channels in the endo …
Abstract
Cyclic ADP-ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate (NAADP) are Ca2+-mobilizing nucleotides that were discovered in the late 1980s. Two decades of investigations have built up a considerable understanding about these two molecules that are related because both are derived from pyridine nucleotides and known to be generated by CD38/ADP-ribosyl cyclases. cADPR has been shown to target the ryanodine receptors in the endoplasmic reticulum whereas NAADP stimulates the two-pore channels in the endo-lysosomes. Accumulating results indicate that cADPR and NAADP are second messenger molecules mediating Ca2+ signaling activated by a wide range of agonists. This article reviews what is known about these two molecules, especially regarding their signaling roles in the pancreatic cells.
Oxford University Press