Expression of G9a in auditory cortex is downregulated in a rat model of age-related hearing loss
Q Li, Y Xiang, X Liang, Y Zhang, P Zhao… - Journal of Molecular …, 2021 - Springer
Q Li, Y Xiang, X Liang, Y Zhang, P Zhao, M Wang, X Bao, X Zhu, A Deng
Journal of Molecular Neuroscience, 2021•SpringerG9a is essential for dendritic plasticity and is associated with neurological disorders. The
possible relationship between age-related hearing loss and G9a expression in the auditory
cortex has not been fully explored. This study aimed to understand the expression patterns
of G9a-mediated histone methylations in the auditory cortex during aging. Using
immunofluorescence and western blotting, we demonstrated that a significant reduction in
G9a expression observed in the auditory cortex of 24-month-old rats compared to 3-month …
possible relationship between age-related hearing loss and G9a expression in the auditory
cortex has not been fully explored. This study aimed to understand the expression patterns
of G9a-mediated histone methylations in the auditory cortex during aging. Using
immunofluorescence and western blotting, we demonstrated that a significant reduction in
G9a expression observed in the auditory cortex of 24-month-old rats compared to 3-month …
Abstract
G9a is essential for dendritic plasticity and is associated with neurological disorders. The possible relationship between age-related hearing loss and G9a expression in the auditory cortex has not been fully explored. This study aimed to understand the expression patterns of G9a-mediated histone methylations in the auditory cortex during aging. Using immunofluorescence and western blotting, we demonstrated that a significant reduction in G9a expression observed in the auditory cortex of 24-month-old rats compared to 3-month-old rats, was associated with remarkable hearing threshold elevation and hair cell loss. Correspondingly, histone H3 lysine 9 (H3K9) mono- and dimethylation (marked by H3K9me1 and H3K9me2, respectively), which were regulated by G9a activity, also evidently decreased during aging. These findings, which merit further investigation, suggest a possible association between G9a-mediated histone methylations and central age-related hearing disorders.
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